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Welcome to the Endometrium Database Resource, EDR. The goal of the EDR is to serve as an evolving Bioinformatics Resource on genes associated with the uterus. The EDR will serve to catalog genes that have been identified as expressed in the uterus in the Gene Database. Here the genes will be characterizes with respect to expression pattern and regulation, as well as, association with any uterine clinical syndrome or mutant phenotype The Gene data base will also link the gene to outside databases containing useful information regarding the specific gene. The EDR will also catalog experiments using DNA microarray analysis and Animal Models to determine the role of specific genes in the uterus. As the EDR develops, researchers will be invited to write reviews on specific issues regarding endometrium research. We will also entertain comments regarding issues involved in endometrium research in our Forum section. The EDR is an evolving database. The EDR will greatly benefit from input from the scientific community and all are welcome to register and enter information into the EDR. The EDR is supported by NICHD/NIH through cooperative agreement (U54) as part of the Specialized Cooperative Centers Program in Reproduction Research.
Gene Database
At the initiation of the EDR we have attempted to build List of Genes which are expressed in the uterus. Our initial focus is on the human and mouse uterus. However, we have also initiated building gene databases for domestic animals (Pig, Sheep, Goat, Bovine and Horse) and nonhuman primates, as well as, other experimental model species (Rat and Rabbit). The EDR gene database contains information regarding temporal and special expression, phenotypic effects of gene disruption, as well as, links to outside resources.While we are building this resource all are welcome to register and add new genes and/or add to information regarding current genes. Any information entered will be viewed by the EDR Staff and be entered into the EDR giving credit to the submitter of this information.
At the initiation of the EDR we have attempted to build List of Genes which are expressed in the uterus. Our initial focus is on the human and mouse uterus. However, we have also initiated building gene databases for domestic animals (Pig, Sheep, Goat, Bovine and Horse) and nonhuman primates, as well as, other experimental model species (Rat and Rabbit). The EDR gene database contains information regarding temporal and special expression, phenotypic effects of gene disruption, as well as, links to outside resources.While we are building this resource all are welcome to register and add new genes and/or add to information regarding current genes. Any information entered will be viewed by the EDR Staff and be entered into the EDR giving credit to the submitter of this information.
Microarray Data
The information entered into the EDR will not only be limited to information regarding a specific gene. One source of entry information for the EDR will be published DNA microarray data. If a manuscript is published showing differential expression of genes in the uterus, the genes described will be annotated and entered into the EDR. Although errors in DNA microarray analysis may erroneously identify a gene as being expressed in the uterus, we feel it is important to identify that gene as being detected as being expressed in the uterus. In the EDR expression table it will be noted that this gene expression was detected in the uterus by micro array analysis. The reader should note that if other supporting information is not associated with the expression of that gene in the uterus, further validation is necessary.
The information entered into the EDR will not only be limited to information regarding a specific gene. One source of entry information for the EDR will be published DNA microarray data. If a manuscript is published showing differential expression of genes in the uterus, the genes described will be annotated and entered into the EDR. Although errors in DNA microarray analysis may erroneously identify a gene as being expressed in the uterus, we feel it is important to identify that gene as being detected as being expressed in the uterus. In the EDR expression table it will be noted that this gene expression was detected in the uterus by micro array analysis. The reader should note that if other supporting information is not associated with the expression of that gene in the uterus, further validation is necessary.